Design and Immunological Evaluation of a Hybrid Peptide as a Potent TLR2 Agonist by Structure-Based Virtual Screening

Design and Immunological Evaluation of a Hybrid Peptide as a Potent TLR2 Agonist by Structure-Based Virtual Screening

Design and Immunological Evaluation of a Hybrid Peptide as a Potent TLR2 Agonist by Structure-Based Virtual Screening

Immunity is a flexible defensive response that’s concerned in defending in opposition to illness by figuring out and destroying self and non-self dangerous substances. As a state of non permanent or everlasting immune dysfunction, immunosuppression could make an organism extra inclined to an infection, organ harm, and most cancers attributable to harm to the immune system. It has taken a very long time to develop new immunomodulatory brokers to forestall and deal with immunosuppressive ailments.

In recent times, Toll-like receptor 2 (TLR2) agonists have been reported to have profound results on the immune system, and they’re thought to be potent immunomodulatory candidates. TP5 and LL-37, the potent immunomodulatory brokers, have been reported to provide a sturdy innate immune response by binding to TLR2. Nevertheless, their growth has been weakened by a number of considerations, reminiscent of potential cytotoxicity, weak physiological stability and poor immunomodulatory exercise.

To beat these challenges, hybridization has been proposed. Due to this fact, six hybrid peptides (LTPa, LTPb, LTPc, TPLa, TPLb, and TPLc) had been designed by combining the full-length TP5 with a attribute fragment of LL-37 that included LL-37 (13-36), LL-37 (17-29), and LL-37 (13-31). LTPa, probably the most potent TLR2 agonist, was merely and successfully screened by molecular docking and in vitro experiments.

Moreover, the immunomodulatory results of LTPa had been confirmed by a CTX-immunosuppressed murine mannequin, which demonstrated that LTPa efficiently inhibit immunosuppression, elevated immune organ indices, enhanced DC maturation, regulated T lymphocyte subsets, and elevated cytokine and Ig contents. Our examine additionally revealed that the immunomodulatory results of LTPa are related to binding to TLR2, forming TLR2 clusters, and activating the NF-κB signaling pathway.

Immunostimulatory TLR7 agonist-nanoparticles along with checkpoint blockade for efficient most cancers immunotherapy

Mono- or dual-checkpoint inhibitors for immunotherapy have modified the paradigm of most cancers care; nevertheless, solely a minority of sufferers responds to such therapy. Combining small molecule immuno-stimulators can enhance therapy efficacy, however they’re restricted by poor pharmacokinetics. On this examine, TLR7 agonists conjugated onto silica nanoparticles confirmed prolonged drug localization after intratumoral injection. The nanoparticle-based TLR7 agonist elevated immune stimulation by activating the TLR7 signaling pathway.

When treating CT26 colon most cancers, nanoparticle conjugated TLR7 agonists elevated T cell infiltration into the tumors by > 4× and upregulated expression of the interferon γ gene in comparison with its unconjugated counterpart by ~2×. Toxicity assays established that the conjugated TLR7 agonist is a protected agent on the efficient dose.

When mixed with checkpoint inhibitors that concentrate on programmed cell demise protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), a 10-100× enhance in immune cell migration was noticed; moreover, 100 mm3 tumors had been handled and a 60% remission price was noticed together with remission at contralateral non-injected tumors. The info present that nanoparticle primarily based TLR7 agonists are protected and might potentiate the effectiveness of checkpoint inhibitors in immunotherapy resistant tumor fashions and promote a long-term particular reminiscence immune operate.

Detrimental Impression of Sigma-1 Receptor Agonist Remedy on Tissue Integrity and Motor Perform Following Spinal Wire Damage

In traumatic spinal wire harm, the preliminary trauma is adopted by a cascade of impairments, together with excitotoxicity and calcium overload, which finally induces secondary damages. The sigma-1 receptor is extensively expressed within the central nervous system and is acknowledged to play a key function in calcium homeostasis. Remedies with agonists of the sigma-1 receptor induce useful results in a number of animal fashions of neurological ailments. In traumatic harm the usage of an antagonist of the sigma-1 receptor reversed a number of signs of central neuropathic ache.

Right here, we investigated whether or not sigma-1 receptor activation with PRE-084 is useful or detrimental following SCI in mice. First, we report that PRE-084 therapy after harm doesn’t enhance motor operate restoration. Second, utilizing ex vivo diffusion weighted magnetic resonance imaging accomplished by histological evaluation, we spotlight that σ1R agonist therapy after SCI doesn’t restrict lesion measurement.

Design and Immunological Evaluation of a Hybrid Peptide as a Potent TLR2 Agonist by Structure-Based Virtual Screening

Lastly, PRE-084 therapy following SCI decreases NeuN expression and will increase astrocytic reactivity. Our findings recommend that activation of sigma-1 receptor after traumatic spinal wire harm is detrimental on tissue preservation and motor operate restoration in mice.

Protecting Impact of Adenosine A 2B Receptor Agonist, BAY60-6583, In opposition to Transient Focal Mind Ischemia in Rat

Cerebral ischemia is a multifactorial pathology characterised first by an acute harm, attributable to excitotoxicity, adopted by a secondary mind harm that develops hours to days after ischemia. Throughout ischemia, adenosine acts as an endogenous neuroprotectant. Few research have investigated the function of A2B receptor in mind ischemia due to the low efficiency of adenosine for it and the few selective ligands developed up to now.

A2B receptors are scarcely however extensively distributed within the mind on neurons, glial and endothelial cells and on hematopoietic cells, lymphocytes and neutrophils, the place they exert primarily anti-inflammatory results, inhibiting vascular adhesion and inflammatory cells migration. Intention of this work was to confirm whether or not continual administration of the A2B agonist, BAY60-6583 (0.1 mg/kg i.p., twice/day), beginning Four h after focal ischemia induced by transient (1 h) Center Cerebral Artery occlusion (tMCAo) within the rat, was protecting after the ischemic insult.

BAY60-6583 improved the neurological deficit as much as 7 days after tMCAo. Seven days after ischemia BAY60-6583 diminished considerably the ischemic mind harm in cortex and striatum, counteracted ischemia-induced neuronal demise, diminished microglia activation and astrocytes alteration. Furthermore, it decreased the expression of TNF-α and elevated that of IL-10 in peripheral plasma.

Dog BH3 Interacting Domain Death Agonist ELISA kit

E08B0306-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog BH3 Interacting Domain Death Agonist ELISA kit

E08B0306-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog BH3 Interacting Domain Death Agonist ELISA kit

E08B0306-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig BH3 Interacting Domain Death Agonist ELISA kit

E07B0306-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig BH3 Interacting Domain Death Agonist ELISA kit

E07B0306-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig BH3 Interacting Domain Death Agonist ELISA kit

E07B0306-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat BH3 Interacting Domain Death Agonist ELISA kit

E06B0306-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat BH3 Interacting Domain Death Agonist ELISA kit

E06B0306-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat BH3 Interacting Domain Death Agonist ELISA kit

E06B0306-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Bid ELISA Kit| Mouse BH3 Interacting Domain Death Agonist ELISA

EF013466 96 Tests
EUR 826.8

BH3-Interacting Domain Death Agonist (BID) ELISA Kit

abx595062-96tests 96 tests
EUR 764.4

Human BH3 Interacting Domain Death Agonist ELISA kit

E01B0306-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human BH3 Interacting Domain Death Agonist ELISA kit

E01B0306-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human BH3 Interacting Domain Death Agonist ELISA kit

E01B0306-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse BH3 Interacting Domain Death Agonist ELISA kit

E03B0306-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse BH3 Interacting Domain Death Agonist ELISA kit

E03B0306-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse BH3 Interacting Domain Death Agonist ELISA kit

E03B0306-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat BH3 Interacting Domain Death Agonist (BID) ELISA Kit

abx256314-96tests 96 tests
EUR 848.4

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

20-abx155258
  • EUR 8684.40
  • EUR 4626.00
  • EUR 1074.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat BH3 Interacting Domain Death Agonist (BID) ELISA Kit

abx572028-96tests 96 tests
EUR 848.4

Pig BH3 Interacting Domain Death Agonist (BID) ELISA Kit

abx360959-96tests 96 tests
EUR 990

Rat BH3 interacting domain death agonist,Bid ELISA Kit

CN-01707R1 96T
EUR 556.8

Rat BH3 interacting domain death agonist,Bid ELISA Kit

CN-01707R2 48T
EUR 375.6

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

DLR-Bid-Ra-48T 48T
EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat BH3 Interacting Domain Death Agonist (Bid) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

DLR-Bid-Ra-96T 96T
EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Rat BH3 Interacting Domain Death Agonist (Bid) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat BH3 interacting domain death agonist(Bid)ELISA Kit

GA-E0045RT-48T 48T
EUR 380.4

Rat BH3 interacting domain death agonist(Bid)ELISA Kit

GA-E0045RT-96T 96T
EUR 595.2

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RDR-Bid-Ra-48Tests 48 Tests
EUR 640.8

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RDR-Bid-Ra-96Tests 96 Tests
EUR 890.4

Rat BH3 interacting domain death agonist(Bid)ELISA Kit

QY-E11608 96T
EUR 433.2

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RD-Bid-Ra-48Tests 48 Tests
EUR 613.2

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RD-Bid-Ra-96Tests 96 Tests
EUR 850.8

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

SEA629Ra-10x96wellstestplate 10x96-wells test plate
EUR 5552.14
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat BH3 Interacting Domain Death Agonist (Bid) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

SEA629Ra-1x48wellstestplate 1x48-wells test plate
EUR 562.42
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat BH3 Interacting Domain Death Agonist (Bid) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

SEA629Ra-1x96wellstestplate 1x96-wells test plate
EUR 752.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat BH3 Interacting Domain Death Agonist (Bid) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

SEA629Ra-5x96wellstestplate 5x96-wells test plate
EUR 3024.07
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat BH3 Interacting Domain Death Agonist (Bid) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

4-SEA629Ra
  • EUR 5612.40
  • EUR 2965.20
  • EUR 752.40
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat BH3 Interacting Domain Death Agonist (Bid) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RD-Bid-Ra-48T 48T
EUR 443.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RD-Bid-Ra-96T 96T
EUR 633.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Rat BH3 interacting domain death agonist,Bid ELISA Kit

YLA0610RA-48T 48T
EUR 465

Rat BH3 interacting domain death agonist,Bid ELISA Kit

YLA0610RA-96T 96T
EUR 600

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RDR-Bid-Ra-48T 48T
EUR 465.47
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Rat BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RDR-Bid-Ra-96T 96T
EUR 664.97
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Bid ELISA Kit| Rat BH3-interacting domain death agonist ELISA Ki

EF017208 96 Tests
EUR 826.8

Rabbit BH3 Interacting Domain Death Agonist ELISA kit

E04B0306-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit BH3 Interacting Domain Death Agonist ELISA kit

E04B0306-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit BH3 Interacting Domain Death Agonist ELISA kit

E04B0306-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey BH3 Interacting Domain Death Agonist ELISA kit

E09B0306-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey BH3 Interacting Domain Death Agonist ELISA kit

E09B0306-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey BH3 Interacting Domain Death Agonist ELISA kit

E09B0306-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human BH3 Interacting Domain Death Agonist (BID) ELISA Kit

abx253938-96tests 96 tests
EUR 848.4

Mouse BH3 Interacting Domain Death Agonist (BID) ELISA Kit

abx255211-96tests 96 tests
EUR 848.4

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

20-abx150808
  • EUR 7970.40
  • EUR 4250.40
  • EUR 990.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Sheep BH3 Interacting Domain Death Agonist (BID) ELISA Kit

abx364093-96tests 96 tests
EUR 1111.2

Human BH3 interacting domain death agonist,Bid ELISA Kit

201-12-1832 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Mouse BH3 Interacting Domain Death Agonist (BID) ELISA Kit

abx572029-96tests 96 tests
EUR 848.4

Human BH3 Interacting Domain Death Agonist (BID) ELISA Kit

abx351363-96tests 96 tests
EUR 848.4

Mouse BH3 interacting domain death agonist,Bid ELISA Kit

CN-02585M1 96T
EUR 565.2

Mouse BH3 interacting domain death agonist,Bid ELISA Kit

CN-02585M2 48T
EUR 386.4

Human BH3 interacting domain death agonist,Bid ELISA Kit

CN-03534H1 96T
EUR 567.6

Human BH3 interacting domain death agonist,Bid ELISA Kit

CN-03534H2 48T
EUR 387.6

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

DLR-Bid-Hu-48T 48T
EUR 574.8
Description: A sandwich quantitative ELISA assay kit for detection of Human BH3 Interacting Domain Death Agonist (Bid) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

DLR-Bid-Hu-96T 96T
EUR 745.2
Description: A sandwich quantitative ELISA assay kit for detection of Human BH3 Interacting Domain Death Agonist (Bid) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

DLR-Bid-Mu-48T 48T
EUR 540
Description: A sandwich quantitative ELISA assay kit for detection of Mouse BH3 Interacting Domain Death Agonist (Bid) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

DLR-Bid-Mu-96T 96T
EUR 698.4
Description: A sandwich quantitative ELISA assay kit for detection of Mouse BH3 Interacting Domain Death Agonist (Bid) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

20-abx153712
  • EUR 7576.80
  • EUR 4042.80
  • EUR 943.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Bid(BH3-interacting domain death agonist) ELISA Kit

ER0336 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.188 ng/ml

Rat Bid/ BH3-interacting domain death agonist ELISA Kit

E0127Ra 1 Kit
EUR 685.2

Mouse BH3 interacting domain death agonist(Bid)ELISA Kit

GA-E0639MS-48T 48T
EUR 403.2

Mouse BH3 interacting domain death agonist(Bid)ELISA Kit

GA-E0639MS-96T 96T
EUR 640.8

Human BH3 interacting domain death agonist(Bid)ELISA Kit

GA-E1848HM-48T 48T
EUR 346.8

Human BH3 interacting domain death agonist(Bid)ELISA Kit

GA-E1848HM-96T 96T
EUR 559.2

Human BH3- interacting domain death agonist, BID ELISA KIT

ELI-02236h 96 Tests
EUR 988.8

Mouse BH3- interacting domain death agonist, Bid ELISA KIT

ELI-02238m 96 Tests
EUR 1038

Mouse Bid(BH3 Interacting Domain Death Agonist) ELISA Kit

EM0871 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA ;Reacts with: Mus ;Sensitivity: 0.188 ng/ml

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RDR-Bid-Hu-48Tests 48 Tests
EUR 600

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RDR-Bid-Hu-96Tests 96 Tests
EUR 830.4

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RDR-Bid-Mu-48Tests 48 Tests
EUR 558

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RDR-Bid-Mu-96Tests 96 Tests
EUR 771.6

Human BH3 Interacting Domain Death Agonist ELISA Kit (Bid)

RK04061 96 Tests
EUR 625.2

Mouse BH3 interacting domain death agonist(Bid)ELISA Kit

QY-E20196 96T
EUR 433.2

Human BH3 interacting domain death agonist(Bid)ELISA Kit

QY-E05112 96T
EUR 433.2

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RD-Bid-Hu-48Tests 48 Tests
EUR 573.6

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RD-Bid-Hu-96Tests 96 Tests
EUR 794.4

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RD-Bid-Mu-48Tests 48 Tests
EUR 535.2

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RD-Bid-Mu-96Tests 96 Tests
EUR 738

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

SEA629Hu-10x96wellstestplate 10x96-wells test plate
EUR 5128.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human BH3 Interacting Domain Death Agonist (Bid) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

SEA629Hu-1x48wellstestplate 1x48-wells test plate
EUR 527.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human BH3 Interacting Domain Death Agonist (Bid) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

SEA629Hu-1x96wellstestplate 1x96-wells test plate
EUR 702.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human BH3 Interacting Domain Death Agonist (Bid) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

SEA629Hu-5x96wellstestplate 5x96-wells test plate
EUR 2799.54
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human BH3 Interacting Domain Death Agonist (Bid) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

4-SEA629Hu
  • EUR 5188.80
  • EUR 2739.60
  • EUR 703.20
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human BH3 Interacting Domain Death Agonist (Bid) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

SEA629Mu-10x96wellstestplate 10x96-wells test plate
EUR 4703.9
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse BH3 Interacting Domain Death Agonist (Bid) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

SEA629Mu-1x48wellstestplate 1x48-wells test plate
EUR 492.55
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse BH3 Interacting Domain Death Agonist (Bid) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

SEA629Mu-1x96wellstestplate 1x96-wells test plate
EUR 652.22
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse BH3 Interacting Domain Death Agonist (Bid) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

SEA629Mu-5x96wellstestplate 5x96-wells test plate
EUR 2575.01
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse BH3 Interacting Domain Death Agonist (Bid) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

4-SEA629Mu
  • EUR 4764.00
  • EUR 2515.20
  • EUR 652.80
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse BH3 Interacting Domain Death Agonist (Bid) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RD-Bid-Hu-48T 48T
EUR 411.8
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RD-Bid-Hu-96T 96T
EUR 588.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RD-Bid-Mu-48T 48T
EUR 380.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RD-Bid-Mu-96T 96T
EUR 543.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse BH3 interacting domain death agonist,Bid ELISA Kit

YLA0948MO-48T 48T
EUR 465

Mouse BH3 interacting domain death agonist,Bid ELISA Kit

YLA0948MO-96T 96T
EUR 600

Human BH3 interacting domain death agonist,Bid ELISA Kit

YLA0008HU-48T 48T
EUR 435

Human BH3 interacting domain death agonist,Bid ELISA Kit

YLA0008HU-96T 96T
EUR 562.5

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RDR-Bid-Hu-48T 48T
EUR 432.39
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RDR-Bid-Hu-96T 96T
EUR 617.72
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RDR-Bid-Mu-48T 48T
EUR 399.32
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA Kit

RDR-Bid-Mu-96T 96T
EUR 570.47
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

ELISA kit for Rat BID (BH3 Interacting Domain Death Agonist)

E-EL-R0107 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Rat BID (BH3 Interacting Domain Death Agonist) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat Bid (BH3 Interacting Domain Death Agonist)

ELK1704 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of BH3 Interacting Domain Death Agonist from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Rabbit BH3 Interacting Domain Death Agonist (BID) ELISA Kit

abx363257-96tests 96 tests
EUR 990

Monkey BH3 Interacting Domain Death Agonist (BID) ELISA Kit

abx359239-96tests 96 tests
EUR 990

Guinea pig BH3 Interacting Domain Death Agonist ELISA kit

E05B0306-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig BH3 Interacting Domain Death Agonist ELISA kit

E05B0306-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig BH3 Interacting Domain Death Agonist ELISA kit

E05B0306-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig BH3 Interacting Domain Death Agonist in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human BAD/ Bcl2-associated agonist of cell death ELISA Kit

E0251Hu 1 Kit
EUR 726

Chicken BH3 Interacting Domain Death Agonist (BID) ELISA Kit

abx356043-96tests 96 tests
EUR 990

Human BID/ BH3-interacting domain death agonist ELISA Kit

E0274Hu 1 Kit
EUR 685.2

Chicken BH3- interacting domain death agonist, BID ELISA KIT

ELI-02235c 96 Tests
EUR 1113.6

Porcine BH3- interacting domain death agonist, BID ELISA KIT

ELI-02237p 96 Tests
EUR 1113.6

Human BID(BH3-interacting domain death agonist) ELISA Kit

EH0983 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

ELISA kit for Mouse BID (BH3 Interacting Domain Death Agonist)

E-EL-M0186 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse BID (BH3 Interacting Domain Death Agonist) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human BID (BH3 Interacting Domain Death Agonist)

E-EL-H0577 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human BID (BH3 Interacting Domain Death Agonist) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse Bid (BH3 Interacting Domain Death Agonist)

ELK1067 1 plate of 96 wells
EUR 446.4
Description: A sandwich ELISA kit for detection of BH3 Interacting Domain Death Agonist from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human Bid (BH3 Interacting Domain Death Agonist)

ELK1703 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of BH3 Interacting Domain Death Agonist from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Guinea pig BH3 Interacting Domain Death Agonist (BID) ELISA Kit

abx357625-96tests 96 tests
EUR 990

Human Cleaved BH3 Interacting Domain Death Agonist (BID) ELISA Kit

abx257411-96tests 96 tests
EUR 848.4

FXR Agonist Assay Kit (TR-FRET)

78131 384 rxns.
EUR 715
Description: The FXR (Farnesoid X Receptor) Agonist Assay Kit (TR-FRET) is designed to measure binding of the FXR and SRC-1 (Steroid Receptor Coactivator 1) for screening FXR agonists using TR-FRET technology. With this homogeneous kit, the FXR agonist assay can be performed by adding all materials, including the detection reagents, to the wells and incubating the plate for 2-hours at room temperature followed by reading the TR-FRET signal._x000D_

Human Cleaved BID/TBID(Cleaved BH3-interacting domain death agonist) ELISA Kit

EH4219 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 4.69pg/ml

STING agonist-1

B7835-10 10 mg
EUR 309.6

STING agonist-1

B7835-50 50 mg
EUR 1120.8

STING agonist-3

HY-103665 5mg
EUR 542.4

STING agonist-1

HY-19711 100mg
EUR 3531.6

STING agonist-4

HY-123943 5mg
EUR 639.6

Wnt agonist 1

B6059-10 10 mg
EUR 164.4
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation.

Wnt agonist 1

B6059-200 200 mg
EUR 901.2
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation.

Wnt agonist 1

B6059-5.1 10 mM (in 1mL DMSO)
EUR 129.6
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation.

Wnt agonist 1

B6059-50 50 mg
EUR 428.4
Description: Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway. The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation.

TPO agonist 1

HY-100380 10mM/1mL
EUR 297.6

FPR Agonist 43

HY-19574 50mg
EUR 1106.4

Smo Agonist, SAG

1939-1 each
EUR 210

Smo Agonist, SAG

1939-5 each
EUR 652.8

PPAR agonist 1

HY-U00340 20mg
EUR 11317.2

MC-4R Agonist 1

HY-U00396 1mg
EUR 5251.2

TLR7 agonist 2

HY-103039 10mg
EUR 1531.2

mGlu2 agonist

A3601-1 1 mg
EUR 254.4
Description: LY2979165 is a novel potent agent that is used as Anti-depressants. LY2979165 is under clinical study. A Safety Study of LY2979165 is performing in Healthy Subjects. LY2979165 is useful for Anti-depressants.

mGlu2 agonist

A3601-10 10 mg
EUR 841.2
Description: LY2979165 is a novel potent agent that is used as Anti-depressants. LY2979165 is under clinical study. A Safety Study of LY2979165 is performing in Healthy Subjects. LY2979165 is useful for Anti-depressants.

mGlu2 agonist

A3601-100 100 mg
EUR 2666.4
Description: LY2979165 is a novel potent agent that is used as Anti-depressants. LY2979165 is under clinical study. A Safety Study of LY2979165 is performing in Healthy Subjects. LY2979165 is useful for Anti-depressants.

mGlu2 agonist

A3601-5 5 mg
EUR 582
Description: LY2979165 is a novel potent agent that is used as Anti-depressants. LY2979165 is under clinical study. A Safety Study of LY2979165 is performing in Healthy Subjects. LY2979165 is useful for Anti-depressants.

mGlu2 agonist

A3601-5.1 10 mM (in 1mL H2O)
EUR 506.4
Description: LY2979165 is a novel potent agent that is used as Anti-depressants. LY2979165 is under clinical study. A Safety Study of LY2979165 is performing in Healthy Subjects. LY2979165 is useful for Anti-depressants.

mGlu2 agonist

A3601-50 50 mg
EUR 2013.6
Description: LY2979165 is a novel potent agent that is used as Anti-depressants. LY2979165 is under clinical study. A Safety Study of LY2979165 is performing in Healthy Subjects. LY2979165 is useful for Anti-depressants.

GPR40 Agonist 2

HY-U00395 5mg
EUR 13828.8

GPR40 agonist 4

HY-103083 100mg
EUR 1093.2

S1P1 Agonist III

HY-12835 10mg
EUR 308.4

Pparδ agonist 2

HY-100120 1mg
EUR 1870.8

STING AGONIST G10

B2047-25 each
EUR 705.6

STING AGONIST G10

B2047-5 each
EUR 222

STING Agonist C11

B2398-1 each
EUR 222

STING Agonist C11

B2398-5 each
EUR 705.6

DREADD Agonist 21

B1924-1 each
EUR 157.2

DREADD Agonist 21

B1924-5 each
EUR 444

GPR120 Agonist 2

HY-111353 100mg
EUR 2952

DREADD agonist 21

HY-100234 10mg
EUR 308.4

Rat BH3 Interacting Domain Death Agonist (BID) CLIA Kit

abx196753-96tests 96 tests
EUR 990

Rat BH3 Interacting Domain Death Agonist (Bid) CLIA Kit

20-abx491792
  • EUR 10282.80
  • EUR 5472.00
  • EUR 1262.40
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Ca2+ channel agonist 1

HY-41076 50mg
EUR 2539.2

Two days after ischemia BAY60-6583 diminished blood cell infiltration within the ischemic cortex. The current examine signifies that A2B receptors stimulation can attenuate the neuroinflammation that develops after ischemia, suggesting that A2B receptors could characterize a brand new attention-grabbing pharmacological goal to guard from degeneration after mind ischemia.

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