Development of hMC1R Selective Small Agonists for Sunless Tanning and Prevention of Genotoxicity of UV in Melanocytes

Activation of the human melanocortin 1 receptor (hMC1R) expressed on melanocytes by α-melanocortin (α-MSH) performs a central function in regulating human pigmentation, and lowering the genotoxicity of ultraviolet radiation (UV) by activating DNA restore and antioxidant defenses. In the direction of growth of a hMC1R-targeted photoprotection technique we designed tetra- and tripeptide agonists with modifications

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