Category: Recombinant Proteins

Development of hMC1R Selective Small Agonists for Sunless Tanning and Prevention of Genotoxicity of UV in Melanocytes

Activation of the human melanocortin 1 receptor (hMC1R) expressed on melanocytes by α-melanocortin (α-MSH) performs a central function in regulating human pigmentation, and lowering the genotoxicity of ultraviolet radiation (UV) by activating DNA restore and antioxidant defenses. In the direction of growth of a hMC1R-targeted photoprotection technique we designed tetra- and tripeptide agonists with modifications

Read More
Anti-PTSD Effects of Hypidone Hydrochloride (YL-0919): A Novel Combined Selective 5-HT Reuptake Inhibitor/5-HT 1A Receptor Partial Agonist/5-HT 6 Receptor Full Agonist

Posttraumatic stress dysfunction (PTSD) is a debilitating trauma and stressor-related dysfunction that has develop into a serious neuropsychiatric downside, resulting in substantial disruptions in particular person well being and societal prices. Our earlier research have demonstrated that hypidone hydrochloride (YL-0919), a novel mixed selective 5-HT reuptake inhibitor/5-HT1A receptor partial agonist/5-HT6 receptor full agonist, exerts notable antidepressant- and

Read More
Design and Immunological Evaluation of a Hybrid Peptide as a Potent TLR2 Agonist by Structure-Based Virtual Screening

Immunity is a flexible defensive response that’s concerned in defending in opposition to illness by figuring out and destroying self and non-self dangerous substances. As a state of non permanent or everlasting immune dysfunction, immunosuppression could make an organism extra inclined to an infection, organ harm, and most cancers attributable to harm to the immune

Read More