Synthesis and Assessment of fused β-carboline derivatives as Kappa Opioid Receptor agonist

The synthesis of 5-formyl-6-aryl-6H-indolo[3,2,1-de][1,5] naphthyridine-2-carboxylates by way of response between 1-formyl-9H-b-carbolines and cinnamaldehydes within the presence of pyrrolidine in water beneath microwave irradiation is described. Pharmacophoric modification of the formyl group provided a number of new fused-b-carboline derivatives which have been investigated for his or her k-opioid receptor (KOR) agonistic exercise. Two compounds 4a and

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