Topigen Pharmaceuticals, Respiratory Research

Synthesis and Assessment of fused β-carboline derivatives as Kappa Opioid Receptor agonist

The synthesis of 5-formyl-6-aryl-6H-indolo[3,2,1-de][1,5] naphthyridine-2-carboxylates by way of response between 1-formyl-9H-b-carbolines and cinnamaldehydes within the presence of pyrrolidine in water beneath microwave irradiation is described. Pharmacophoric modification of the formyl group provided a number of new fused-b-carboline derivatives which have been investigated for his or her k-opioid receptor (KOR) agonistic exercise.

Two compounds 4a and 4c produced considerable agonist exercise on KOR with EC50 of 46±19 nM and 134±9 nM, respectively. Furthermore, compound induced KOR signaling research advised each compounds to be extraordinarily G-protein biased agonist. The analgesic impact of 4a was validated by the rise in tail flick latency in time dependent method, which was utterly blocked by KOR selective antagonist norBNI. Furthermore, not like U50488, an unbaised full KOR agonist, 4a didn’t induce sedation. The docking of 4a with the human KOR was studied to rationalize the consequence.

The results of an alpha-2-adrenoceptor agonist, antagonist, and their mixture on the blood insulin, glucose, and glucagon concentrations in insulin delicate and dysregulated horses

Alpha-2-adrenoceptor agonists are sedatives that may trigger fluctuations in serum insulin and blood glucose (BG) concentrations in horses. The aims of this examine have been to analyze the results of detomidine and vatinoxan on BG, insulin, and glucagon concentrations in horses with and with out insulin dysregulation (ID). In a blinded cross-over design, eight horses with ID and eight horses with out ID have been assigned to every of 4 therapies: detomidine (0.02 mg/kg; DET), vatinoxan (0.2 mg/kg; VAT), detomidine + vatinoxan (DET + VAT), and saline management (SAL). Blood samples have been taken at 0, 1, 2, 4, 6, and eight h.

Change from baseline was used because the response in modelling, and the variations between therapies have been evaluated with repeated measures evaluation of covariance. P values ≤0.05 have been thought-about important. Evaluating DET vs. SAL and DET vs. DET + VAT, insulin was larger at 2 h within the non-ID group and a pair of and Four h within the ID group.

There was no distinction in insulin between SAL and DET + VAT or VAT. Evaluating DET vs. SAL, BG was larger at 1 and a pair of h then was decrease at Four h in each ID and non-ID teams. At 1 h in each teams, BG after DET + VAT was decrease than after DET however larger than after SAL. Evaluating DET vs. SAL, glucagon was decrease at 1 h within the ID group and 1 and a pair of h within the non-ID group. Vatinoxan was efficient in stopping detomidine-induced hyperglycaemia in addition to the following insulin improve in horses with ID.

The selective 5-HT2A receptor agonist 25CN-NBOH doesn’t have an effect on reversal studying in mice

Psychedelic 5-hydroxytryptamine 2A receptor (5-HT2AR) agonists are displaying promise within the therapy of psychiatric problems, comparable to treatment-resistant despair and nervousness. Human research recommend that enhanced cognitive flexibility could contribute to their medical efficacy. Each enchancment and impairment of cognitive flexibility has been reported with 5-HT2AR ligands, making the hyperlink between 5-HT2AR pharmacology and cognitive flexibility equivocal.

We examined the selective 5-HT2AR agonist 25CN-NBOH in wholesome male C57BL/6JOlaHsd mice in a touchscreen-based mouse reversal studying take a look at. No results have been noticed on acquisition of the brand new stimulus-reward contingency, studying errors, or perseverative responses throughout reversal. Our outcomes recommend that 25CN-NBOH doesn’t have an effect on reversal studying within the schedule used on this examine.

β-caryophyllene, a pure bicyclic sesquiterpene attenuates β-adrenergic agonist-induced myocardial harm in a cannabinoid receptor-2 dependent and impartial method

The downregulation of cannabinoid type-2 receptors (CB2R) have been reported in quite a few illnesses together with cardiovascular illnesses (CVDs). The activation of CB2R has been just lately emerged as an necessary therapeutic goal to mitigate myocardial harm. We examined whether or not CB2R activation can shield towards isoproterenol (ISO)-induced myocardial harm (MI) in rats. Within the current examine, we investigated the cardioprotective impact of β-caryophyllene (BCP), a naturally occurring dietary cannabinoid in rat mannequin of MI.

Rats have been pre- and co-treated with BCP (50 mg/kg, orally) twice day by day for 10 days together with subcutaneous injection of ISO (85 mg/kg) at an interval of 24 h for 2 days (9^th and 10^th days). AM630 (1 mg/kg), a CB2 receptor antagonist, was injected intraperitoneal as a pharmacological problem previous to BCP therapy to disclose CB2R-mediated cardioprotective mechanisms of BCP.

Desensitization of beta-adrenergic receptor (β-AR) signaling, receptor phosphorylation and recruitment of adapter β-arrestins have been noticed in ISO-induced MI in rats. ISO injections triggered impaired cardiac operate, elevated the degrees of serum cardiac marker enzymes, and enhanced oxidative stress markers together with altered PI3K/Akt and NrF2/Keap1/HO-1 signaling pathways.

ISO additionally promoted lysosomal dysfunction together with activation of NLRP3 inflammasomes and TLR4-NFκB/MAPK signaling and triggered rise in proinflammatory cytokines. There was a concomitant mitochondrial dysfunction adopted by the activation of endoplasmic reticulum (ER) stress-mediated Hippo signaling and intrinsic pathway of apoptosis in addition to altered autophagic flux/mTOR signaling was noticed in ISO-induced MI.

Moreover, ISO additionally triggered dyslipidemia evidenced by altered lipids, lipoproteins and lipid marker enzymes together with adjustments in ionic homeostasis malfunction. IHowever, therapy with BCP resulted in important protecting results on all biochemical and molecular parameters analyzed. The cardioprotective results have been additional strengthened by preservation of cardiomyocytes and cell organelles as noticed in histopathological and ultrastructural research.

glucagon receptor antagonists 3
A3437-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 598.8
Description: highly potent glucagon receptor antagonist

Glucagon receptor antagonists-2
HY-50158	MedChemExpress	5mg	EUR 433.2

Glucagon receptor antagonists-3
HY-50159	MedChemExpress	5mg	EUR 433.2

Glucagon receptor antagonists-1
HY-10036	MedChemExpress	10mg	EUR 730.8

GAD (Anti-glutamic acid decarboxylase antibody) ELISA test
27	Biobase	96T/Box	Ask for price
Description: ELISA based test for quantitative detection of GAD (Anti-glutamic acid decarboxylase antibody)

Calcium-Sensing Receptor Antagonists I
A3275-10	ApexBio	10 mg	EUR 614.4
Description: Calcium-Sensing Receptor Antagonists I is antagonists of calcium-sensing parathyroid hormone receptors.

Calcium-Sensing Receptor Antagonists I
A3275-100	ApexBio	100 mg	EUR 2245.2
Description: Calcium-Sensing Receptor Antagonists I is antagonists of calcium-sensing parathyroid hormone receptors.

Calcium-Sensing Receptor Antagonists I
A3275-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 672
Description: Calcium-Sensing Receptor Antagonists I is antagonists of calcium-sensing parathyroid hormone receptors.

Calcium-Sensing Receptor Antagonists I
HY-50713	MedChemExpress	10mM/1mL	EUR 525.6

Lyophilized Exosome Standard (Human Saliva)
ESL-27	Creative Biolabs	30 µgx6 vials	EUR 3627.6
Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.

Anti-Crotonyl-Histone H3 (Lys9) Rabbit Monoclonal Antibody, Clone#RM339
M06819-27	BosterBio	100ug	EUR 561.6
Description: Anti-Crotonyl-Histone H3 (Lys9) Rabbit Monoclonal Antibody, Clone#RM339 tested in WB, ELISA, Multiplex, ChIP, reactive to All Vertebrates

Human Factor X (Factor 10) AssayMax ELISA Kit (Positive Control included)
EF1010-27	AssayPro	96 Well Plate	EUR 643.2

Human Fibrinogen (FBG) AssayMax ELISA Kit (Positive Control included)
EF1040-27	AssayPro	96 Well Plate	EUR 546

Human Apolipoprotein C-I (Apo C1) AssayMax ELISA Kit (Positive Control included)
EA8011-27	AssayPro	96 Well Plate	EUR 572.4

IL-16, Interleukin-16 (121a.a), human
RC212-27	Bio Basic	10ug	EUR 203.56

CDNF, human
RC218-27	Bio Basic	5ug	EUR 125.26

IL-16, Interleukin-16, monkey
RC222-27	Bio Basic	2ug	EUR 125.26

IL-16, murine (mouse)
RC232-27	Bio Basic	2ug	EUR 125.26

HCC-4, LEC, NCC-4, CCL16, human
RC315-27	Bio Basic	5ug	EUR 125.26

CXCL16, murine (mouse)
RC332-27	Bio Basic	5ug	EUR 125.26

MIA-2, Melanoma Inhibitor Activity Protein 2, human
RC712-27	Bio Basic	5ug	EUR 125.26

Interleukin 27 (IL-27) Antibody
20-abx225246	Abbexa	EUR 444.00 EUR 727.20 EUR 376.80	100 ul 200 ul 50 ul

Interleukin 27 (IL-27) Antibody
abx234259-100ug	Abbexa	100 ug	EUR 661.2

Interleukin 27 (IL-27) Antibody
abx234260-100ug	Abbexa	100 ug	EUR 661.2

Integrin?
ABF5152	Lifescience Market	100 ug	EUR 525.6

Integrin?
ABF5155	Lifescience Market	100 ug	EUR 525.6

Integrin?
ABF5182	Lifescience Market	100 ug	EUR 525.6

Integrin?
ABF5200	Lifescience Market	100 ug	EUR 525.6

Integrin
ABF5327	Lifescience Market	100 ug	EUR 525.6

Integrin
ABF5346	Lifescience Market	100 ug	EUR 525.6

Integrin
ABF5379	Lifescience Market	100 ug	EUR 525.6

Integrin
ABF8071	Lifescience Market	100 ug	EUR 525.6

27-Hydroxycholesterol (27-HC) ELISA Kit
abx257403-96tests	Abbexa	96 tests	EUR 764.4

Gap 27
A1045-10	ApexBio	10 mg	EUR 373.2
Description: Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker.Connexins, or gap junctions, are a family of structurally-related transmembrane proteins.

Gap 27
A1045-25	ApexBio	25 mg	EUR 498
Description: Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker.Connexins, or gap junctions, are a family of structurally-related transmembrane proteins.

Gap 27
A1045-5	ApexBio	5 mg	EUR 247.2
Description: Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker.Connexins, or gap junctions, are a family of structurally-related transmembrane proteins.

27-Hydroxycholesterol
B2988-1	Biovision	1mg	EUR 199.2

27-Hydroxycholesterol
B2988-5	Biovision	5mg	EUR 612

27-Hydroxycholesterol
HY-N2371	MedChemExpress	10mM/1mL	EUR 367.2

27-Deoxyactein
HY-N6264	MedChemExpress	5mg	EUR 614.4

Gap 27
HY-P0139	MedChemExpress	5mg	EUR 274.8

VTX-27
HY-112782	MedChemExpress	100mg	EUR 5499.6

GAP 27
H-7592.0500	Bachem	0.5mg	EUR 85.2
Description: Sum Formula: C60H101N15O17; CAS# [198284-64-9] net

GAP 27
H-7592.1000	Bachem	1.0mg	EUR 122.4
Description: Sum Formula: C60H101N15O17; CAS# [198284-64-9] net

27-Hydroxycholesterol
TBZ2137	ChemNorm	20mg	Ask for price

27-Deoxyactein
TBZ2209	ChemNorm	10mg	Ask for price

27-Dimethylnaphthalene
S-1641	Scientific Laboratory Supplies	1ML	EUR 328.32

Human Peptide Histidine-Methionine 27 (PHM-27) peptide (27-aa, amide)
PHM65-P-500	Alpha Diagnostics	500 ug	EUR 343.2

Rat Interleukin 27,IL-27 ELISA Kit
CN-01431R1	ChemNorm	96T	EUR 520.8

Rat Interleukin 27,IL-27 ELISA Kit
CN-01431R2	ChemNorm	48T	EUR 340.8

Human Interleukin 27, IL-27 ELISA Kit
CSB-E08464h-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 27, IL-27 in samples from serum, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 27, IL-27 ELISA Kit
1-CSB-E08464h	Cusabio	EUR 723.60 EUR 5096.40 EUR 2712.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 27, IL-27 in samples from serum, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Interleukin 27, IL-27 ELISA Kit
CSB-E08465r-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 27, IL-27 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Interleukin 27, IL-27 ELISA Kit
1-CSB-E08465r	Cusabio	EUR 723.60 EUR 5096.40 EUR 2712.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 27, IL-27 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Interleukin 27, IL-27 ELISA Kit
CSB-E08466m-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 27, IL-27 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Interleukin 27, IL-27 ELISA Kit
1-CSB-E08466m	Cusabio	EUR 723.60 EUR 5096.40 EUR 2712.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 27, IL-27 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

human Interleukin 27,IL-27 ELISA Kit
CN-03350H1	ChemNorm	96T	EUR 529.2

human Interleukin 27,IL-27 ELISA Kit
CN-03350H2	ChemNorm	48T	EUR 349.2

Mouse Interleukin 27,IL-27 ELISA Kit
CN-02300M1	ChemNorm	96T	EUR 537.6

Mouse Interleukin 27,IL-27 ELISA Kit
CN-02300M2	ChemNorm	48T	EUR 356.4

Mouse IL-27(Interleukin 27) ELISA Kit
EM1811	FN Test	96T	EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 4.688pg/ml

Canine Interleukin 27(IL-27)ELISA Kit
GA-E0072CN-48T	GenAsia Biotech	48T	EUR 482.4

Canine Interleukin 27(IL-27)ELISA Kit
GA-E0072CN-96T	GenAsia Biotech	96T	EUR 820.8

Human Interleukin 27(IL-27)ELISA Kit
GA-E0115HM-48T	GenAsia Biotech	48T	EUR 346.8

Human Interleukin 27(IL-27)ELISA Kit
GA-E0115HM-96T	GenAsia Biotech	96T	EUR 559.2

Rat Interleukin 27(IL-27)ELISA Kit
GA-E0135RT-48T	GenAsia Biotech	48T	EUR 403.2

Rat Interleukin 27(IL-27)ELISA Kit
GA-E0135RT-96T	GenAsia Biotech	96T	EUR 640.8

Human 27 OHC(27-Hydroxycholesterol) ELISA Kit
EH4025	FN Test	96T	EUR 628.92
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375 ng/ml

Rat IL-27(Interleukin 27) ELISA Kit
ER1098	FN Test	96T	EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml

human Interleukin 27,IL-27 ELISA Kit
201-12-0076	SunredBio	96 tests	EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Mouse Interleukin 27 (IL-27) CLIA Kit
abx197191-96tests	Abbexa	96 tests	EUR 990

Rat Interleukin 27 (IL-27) CLIA Kit
abx197192-96tests	Abbexa	96 tests	EUR 990

IL-27/ Rat IL- 27 ELISA Kit
ELA-E0385r	Lifescience Market	96 Tests	EUR 1063.2

HSP-27/ Rat HSP- 27 ELISA Kit
ELA-E0693r	Lifescience Market	96 Tests	EUR 1063.2

Mouse Interleukin 27(IL-27)ELISA Kit
GA-E0530MS-48T	GenAsia Biotech	48T	EUR 403.2

Mouse Interleukin 27(IL-27)ELISA Kit
GA-E0530MS-96T	GenAsia Biotech	96T	EUR 640.8

IL-27 Interleukin-27 Mouse Recombinant Protein
PROTQ8K3I6	BosterBio	Regular: 10ug	EUR 380.4
Description: Interleukin-27 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 207 amino acids and having a molecular mass of 23.7 kDa. ;The Murine IL-27 is purified by proprietary chromatographic techniques.

IL-27 Interleukin-27 Human Recombinant Protein
PROTQ8NEV9	BosterBio	Regular: 5ug	EUR 380.4
Description: IL-27 Human Recombinant produced in HEK cells is a glycosylated non-covalently heterodimer that consists of 2 chains, IL27A (IL27p28) having a Mw of 25kDa and IL27B (EBI3) having a Mw of 30kDa. Each chain migrates separately on SDS-PAGE. The IL-27 protein is purified by proprietary chromatographic techniques

Human Interleukin 27(IL-27)ELISA Kit
QY-E04284	Qayee Biotechnology	96T	EUR 433.2

Rat Interleukin 27(IL-27)ELISA Kit
QY-E11518	Qayee Biotechnology	96T	EUR 433.2

Mouse Interleukin 27(IL-27)ELISA Kit
QY-E20855	Qayee Biotechnology	96T	EUR 433.2

Rat Interleukin 27,IL-27 ELISA Kit
YLA0497RA-48T	Shanghai YL Biotech	48T	EUR 465

Rat Interleukin 27,IL-27 ELISA Kit
YLA0497RA-96T	Shanghai YL Biotech	96T	EUR 600

Mouse Interleukin 27,IL-27 ELISA Kit
YLA0890MO-48T	Shanghai YL Biotech	48T	EUR 465

Mouse Interleukin 27,IL-27 ELISA Kit
YLA0890MO-96T	Shanghai YL Biotech	96T	EUR 600

human Interleukin 27,IL-27 ELISA Kit
YLA0684HU-48T	Shanghai YL Biotech	48T	EUR 435

human Interleukin 27,IL-27 ELISA Kit
YLA0684HU-96T	Shanghai YL Biotech	96T	EUR 562.5

ELISA kit for Human IL-27 (Interleukin 27)
E-EL-H2338	Elabscience Biotech	1 plate of 96 wells	EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human IL-27 (Interleukin 27) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse IL-27 (Interleukin 27)
E-EL-M0732	Elabscience Biotech	1 plate of 96 wells	EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse IL-27 (Interleukin 27) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat IL-27 (Interleukin 27)
E-EL-R0570	Elabscience Biotech	1 plate of 96 wells	EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Rat IL-27 (Interleukin 27) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat IL-27 (Interleukin 27)
E-EL-R1223	Elabscience Biotech	1 plate of 96 wells	EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Rat IL-27 (Interleukin 27) in samples from Serum, Plasma, Cell supernatant

Recombinant Mouse Interleukin-27/IL-27 (C-6His)
CS44-10ug	Novoprotein	10ug	EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Interleukin-27/IL-27 (C-6His)
CS44-1mg	Novoprotein	1mg	EUR 4322.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Interleukin-27/IL-27 (C-6His)
CS44-500ug	Novoprotein	500ug	EUR 3043.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Interleukin-27/IL-27 (C-6His)
CS44-50ug	Novoprotein	50ug	EUR 717.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

CLIA kit for Mouse IL-27 (Interleukin 27)
E-CL-M0465	Elabscience Biotech	1 plate of 96 wells	EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Mouse IL-27 (Interleukin 27) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Rat IL-27 (Interleukin 27)
E-CL-R0404	Elabscience Biotech	1 plate of 96 wells	EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Rat IL-27 (Interleukin 27) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rabbit Interleukin 27 (IL-27)
KTE90157-48T	Abbkine	48T	EUR 457.2
Description: Quantitative sandwich ELISA for measuring Rabbit Interleukin 27 (IL-27) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rabbit Interleukin 27 (IL-27)
KTE90157-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 3194.4
Description: Quantitative sandwich ELISA for measuring Rabbit Interleukin 27 (IL-27) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rabbit Interleukin 27 (IL-27)
KTE90157-96T	Abbkine	96T	EUR 802.8
Description: Quantitative sandwich ELISA for measuring Rabbit Interleukin 27 (IL-27) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Human Matrix Metalloproteinase 27(MMP-27)ELISA Kit
QY-E02985	Qayee Biotechnology	96T	EUR 433.2

IL-27 Antibody
3797-002mg	ProSci	0.02 mg	EUR 206.18
Description: IL-27 Antibody: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.

IL-27 Antibody
3797-01mg	ProSci	0.1 mg	EUR 523.7
Description: IL-27 Antibody: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.

IL-27 Peptide
3797P	ProSci	0.05 mg	EUR 197.7
Description: (NT) IL-27 peptide

IL-27 Antibody
3799-002mg	ProSci	0.02 mg	EUR 206.18
Description: IL-27 Antibody: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.

IL-27 Antibody
3799-01mg	ProSci	0.1 mg	EUR 523.7
Description: IL-27 Antibody: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.

IL-27 Peptide
3799P	ProSci	0.05 mg	EUR 197.7
Description: (IN) IL-27 peptide

IL-27 Antibody
24412-100ul	SAB	100ul	EUR 468

IL-27 Antibody
24413-100ul	SAB	100ul	EUR 468

SeedG-27 Antibody
abx018403-100ul	Abbexa	100 ul	EUR 460.8

OsMYB-27 Antibody
abx018575-100ul	Abbexa	100 ul	EUR 460.8

PACAP 1-27
B5075-.5	ApexBio	500 ?g	EUR 277.2

PACAP 1-27
B5075-1	ApexBio	1 mg	EUR 348

PACAP 1-27
B5075-5	ApexBio	5 mg	EUR 927.6

PHM 27 (human)
B5254-1	ApexBio	1 mg	EUR 478.8

FGIN-1-27
B6394-10	ApexBio	10 mg	EUR 151.2

FGIN-1-27
B6394-25	ApexBio	25 mg	EUR 205.2

FGIN-1-27
B6394-50	ApexBio	50 mg	EUR 327.6

(R)-BPO-27
HY-19778	MedChemExpress	100mg	EUR 3531.6

BPO-27 (racemate)
HY-19778A	MedChemExpress	10mg	EUR 886.8

PHI-27 (porcine)
H-3730.0500	Bachem	0.5mg	EUR 400.8
Description: Sum Formula: C136H216N36O40; CAS# [80458-29-3]

PHI-27 (porcine)
H-3730.1000	Bachem	1.0mg	EUR 618
Description: Sum Formula: C136H216N36O40; CAS# [80458-29-3]

PHM-27 (human)
H-6355.0500	Bachem	0.5mg	EUR 400.8
Description: Sum Formula: C135H214N34O40S; CAS# [87403-73-4] net

PHM-27 (human)
H-6355.1000	Bachem	1.0mg	EUR 618
Description: Sum Formula: C135H214N34O40S; CAS# [87403-73-4] net

PHI-27 (rat)
H-7760.0500	Bachem	0.5mg	EUR 400.8
Description: Sum Formula: C136H216N36O41; CAS# [96849-38-6]

PHI-27 (rat)
H-7760.1000	Bachem	1.0mg	EUR 618
Description: Sum Formula: C136H216N36O41; CAS# [96849-38-6]

27-Hydroxymangiferonic acid
TB02479	ChemNorm	5mg	EUR 1164

121817-27-4
TBZ30118	ChemNorm	unit	Ask for price

Rat heat shock protein 27,HSP-27 ELISA Kit
CN-01689R1	ChemNorm	96T	EUR 526.8

Rat heat shock protein 27,HSP-27 ELISA Kit
CN-01689R2	ChemNorm	48T	EUR 348

Rat heat shock protein 27, HSP-27 ELISA Kit
CSB-E09240r-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat heat shock protein 27, HSP-27 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat heat shock protein 27, HSP-27 ELISA Kit
1-CSB-E09240r	Cusabio	EUR 843.60 EUR 5811.60 EUR 3084.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat heat shock protein 27, HSP-27 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Chicken Heat Shock Protein 27, HSP-27 ELISA Kit
CSB-E12879C-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativecompetitive ELISA kit for measuring Chicken Heat Shock Protein 27, HSP-27 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Chicken Heat Shock Protein 27, HSP-27 ELISA Kit
1-CSB-E12879C	Cusabio	EUR 843.60 EUR 5811.60 EUR 3084.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativecompetitive ELISA kit for measuring Chicken Heat Shock Protein 27, HSP-27 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human heat shock protein 27,HSP-27 ELISA Kit
CN-04317H1	ChemNorm	96T	EUR 526.8

Human heat shock protein 27,HSP-27 ELISA Kit
CN-04317H2	ChemNorm	48T	EUR 348

Mouse heat shock protein 27,HSP-27 ELISA Kit
CN-02561M1	ChemNorm	96T	EUR 556.8

Mouse heat shock protein 27,HSP-27 ELISA Kit
CN-02561M2	ChemNorm	48T	EUR 375.6

Mouse HSP-27(heat shock protein 27) ELISA Kit
EM1135	FN Test	96T	EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.375 ng/ml

Rat HSP-27(Heat Shock Protein 27) ELISA Kit
ER1053	FN Test	96T	EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.469 ng/ml

Rat Heat Shock Protein 27 (HSP-27) CLIA Kit
abx197103-96tests	Abbexa	96 tests	EUR 990

Human heat shock protein 27,HSP-27 ELISA Kit
201-12-1787	SunredBio	96 tests	EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human IL-27(Interleukin-27 subunit alpha) ELISA Kit
EH0193	FN Test	96T	EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

IL-27 ELISA Kit| Rat Interleukin 27 ELISA Kit
EF017845	Lifescience Market	96 Tests	EUR 826.8

Apparently, therapy with AM630, a CB2R antagonist was noticed to abrogate the protecting results of BCP on the biochemical and molecular parameters besides hyperlipidemia and ionic homeostasis in ISO-induced MI in rats. The current examine findings display that BCP possess the potential to guard myocardium towards ISO-induced MI in a CB2-dependent and impartial method.