Synthesis and Assessment of fused β-carboline derivatives as Kappa Opioid Receptor agonist
The synthesis of 5-formyl-6-aryl-6H-indolo[3,2,1-de][1,5] naphthyridine-2-carboxylates by way of response between 1-formyl-9H-b-carbolines and cinnamaldehydes within the presence of pyrrolidine in water beneath microwave irradiation is described. Pharmacophoric modification of the formyl group provided a number of new fused-b-carboline derivatives which have been investigated for his or her k-opioid receptor (KOR) agonistic exercise.
Two compounds 4a and 4c produced considerable agonist exercise on KOR with EC50 of 46±19 nM and 134±9 nM, respectively. Furthermore, compound induced KOR signaling research advised each compounds to be extraordinarily G-protein biased agonist. The analgesic impact of 4a was validated by the rise in tail flick latency in time dependent method, which was utterly blocked by KOR selective antagonist norBNI. Furthermore, not like U50488, an unbaised full KOR agonist, 4a didn’t induce sedation. The docking of 4a with the human KOR was studied to rationalize the consequence.
The results of an alpha-2-adrenoceptor agonist, antagonist, and their mixture on the blood insulin, glucose, and glucagon concentrations in insulin delicate and dysregulated horses
Alpha-2-adrenoceptor agonists are sedatives that may trigger fluctuations in serum insulin and blood glucose (BG) concentrations in horses. The aims of this examine have been to analyze the results of detomidine and vatinoxan on BG, insulin, and glucagon concentrations in horses with and with out insulin dysregulation (ID). In a blinded cross-over design, eight horses with ID and eight horses with out ID have been assigned to every of 4 therapies: detomidine (0.02 mg/kg; DET), vatinoxan (0.2 mg/kg; VAT), detomidine + vatinoxan (DET + VAT), and saline management (SAL). Blood samples have been taken at 0, 1, 2, 4, 6, and eight h.
Change from baseline was used because the response in modelling, and the variations between therapies have been evaluated with repeated measures evaluation of covariance. P values ≤0.05 have been thought-about important. Evaluating DET vs. SAL and DET vs. DET + VAT, insulin was larger at 2 h within the non-ID group and a pair of and Four h within the ID group.
There was no distinction in insulin between SAL and DET + VAT or VAT. Evaluating DET vs. SAL, BG was larger at 1 and a pair of h then was decrease at Four h in each ID and non-ID teams. At 1 h in each teams, BG after DET + VAT was decrease than after DET however larger than after SAL. Evaluating DET vs. SAL, glucagon was decrease at 1 h within the ID group and 1 and a pair of h within the non-ID group. Vatinoxan was efficient in stopping detomidine-induced hyperglycaemia in addition to the following insulin improve in horses with ID.
The selective 5-HT2A receptor agonist 25CN-NBOH doesn’t have an effect on reversal studying in mice
Psychedelic 5-hydroxytryptamine 2A receptor (5-HT2AR) agonists are displaying promise within the therapy of psychiatric problems, comparable to treatment-resistant despair and nervousness. Human research recommend that enhanced cognitive flexibility could contribute to their medical efficacy. Each enchancment and impairment of cognitive flexibility has been reported with 5-HT2AR ligands, making the hyperlink between 5-HT2AR pharmacology and cognitive flexibility equivocal.
We examined the selective 5-HT2AR agonist 25CN-NBOH in wholesome male C57BL/6JOlaHsd mice in a touchscreen-based mouse reversal studying take a look at. No results have been noticed on acquisition of the brand new stimulus-reward contingency, studying errors, or perseverative responses throughout reversal. Our outcomes recommend that 25CN-NBOH doesn’t have an effect on reversal studying within the schedule used on this examine.
β-caryophyllene, a pure bicyclic sesquiterpene attenuates β-adrenergic agonist-induced myocardial harm in a cannabinoid receptor-2 dependent and impartial method
The downregulation of cannabinoid type-2 receptors (CB2R) have been reported in quite a few illnesses together with cardiovascular illnesses (CVDs). The activation of CB2R has been just lately emerged as an necessary therapeutic goal to mitigate myocardial harm. We examined whether or not CB2R activation can shield towards isoproterenol (ISO)-induced myocardial harm (MI) in rats. Within the current examine, we investigated the cardioprotective impact of β-caryophyllene (BCP), a naturally occurring dietary cannabinoid in rat mannequin of MI.
Rats have been pre- and co-treated with BCP (50 mg/kg, orally) twice day by day for 10 days together with subcutaneous injection of ISO (85 mg/kg) at an interval of 24 h for 2 days (9th and 10th days). AM630 (1 mg/kg), a CB2 receptor antagonist, was injected intraperitoneal as a pharmacological problem previous to BCP therapy to disclose CB2R-mediated cardioprotective mechanisms of BCP.

Desensitization of beta-adrenergic receptor (β-AR) signaling, receptor phosphorylation and recruitment of adapter β-arrestins have been noticed in ISO-induced MI in rats. ISO injections triggered impaired cardiac operate, elevated the degrees of serum cardiac marker enzymes, and enhanced oxidative stress markers together with altered PI3K/Akt and NrF2/Keap1/HO-1 signaling pathways.
ISO additionally promoted lysosomal dysfunction together with activation of NLRP3 inflammasomes and TLR4-NFκB/MAPK signaling and triggered rise in proinflammatory cytokines. There was a concomitant mitochondrial dysfunction adopted by the activation of endoplasmic reticulum (ER) stress-mediated Hippo signaling and intrinsic pathway of apoptosis in addition to altered autophagic flux/mTOR signaling was noticed in ISO-induced MI.
Moreover, ISO additionally triggered dyslipidemia evidenced by altered lipids, lipoproteins and lipid marker enzymes together with adjustments in ionic homeostasis malfunction. IHowever, therapy with BCP resulted in important protecting results on all biochemical and molecular parameters analyzed. The cardioprotective results have been additional strengthened by preservation of cardiomyocytes and cell organelles as noticed in histopathological and ultrastructural research.
glucagon receptor antagonists 3 |
A3437-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 598.8 |
Description: highly potent glucagon receptor antagonist |
Glucagon receptor antagonists-1 |
HY-10036 |
MedChemExpress |
10mg |
EUR 730.8 |
GAD (Anti-glutamic acid decarboxylase antibody) ELISA test |
27 |
Biobase |
96T/Box |
Ask for price |
|
Description: ELISA based test for quantitative detection of GAD (Anti-glutamic acid decarboxylase antibody) |
Calcium-Sensing Receptor Antagonists I |
A3275-10 |
ApexBio |
10 mg |
EUR 614.4 |
Description: Calcium-Sensing Receptor Antagonists I is antagonists of calcium-sensing parathyroid hormone receptors. |
Calcium-Sensing Receptor Antagonists I |
A3275-100 |
ApexBio |
100 mg |
EUR 2245.2 |
Description: Calcium-Sensing Receptor Antagonists I is antagonists of calcium-sensing parathyroid hormone receptors. |
Calcium-Sensing Receptor Antagonists I |
A3275-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 672 |
Description: Calcium-Sensing Receptor Antagonists I is antagonists of calcium-sensing parathyroid hormone receptors. |
Calcium-Sensing Receptor Antagonists I |
HY-50713 |
MedChemExpress |
10mM/1mL |
EUR 525.6 |
Lyophilized Exosome Standard (Human Saliva) |
ESL-27 |
Creative Biolabs |
30 µgx6 vials |
EUR 3627.6 |
Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples. |
Anti-Crotonyl-Histone H3 (Lys9) Rabbit Monoclonal Antibody, Clone#RM339 |
M06819-27 |
BosterBio |
100ug |
EUR 561.6 |
Description: Anti-Crotonyl-Histone H3 (Lys9) Rabbit Monoclonal Antibody, Clone#RM339 tested in WB, ELISA, Multiplex, ChIP, reactive to All Vertebrates |
Human Factor X (Factor 10) AssayMax ELISA Kit (Positive Control included) |
EF1010-27 |
AssayPro |
96 Well Plate |
EUR 643.2 |
Human Fibrinogen (FBG) AssayMax ELISA Kit (Positive Control included) |
EF1040-27 |
AssayPro |
96 Well Plate |
EUR 546 |
Human Apolipoprotein C-I (Apo C1) AssayMax ELISA Kit (Positive Control included) |
EA8011-27 |
AssayPro |
96 Well Plate |
EUR 572.4 |
IL-16, Interleukin-16 (121a.a), human |
RC212-27 |
Bio Basic |
10ug |
EUR 203.56 |
|
CDNF, human |
RC218-27 |
Bio Basic |
5ug |
EUR 125.26 |
|
IL-16, Interleukin-16, monkey |
RC222-27 |
Bio Basic |
2ug |
EUR 125.26 |
|
IL-16, murine (mouse) |
RC232-27 |
Bio Basic |
2ug |
EUR 125.26 |
|
HCC-4, LEC, NCC-4, CCL16, human |
RC315-27 |
Bio Basic |
5ug |
EUR 125.26 |
|
CXCL16, murine (mouse) |
RC332-27 |
Bio Basic |
5ug |
EUR 125.26 |
|
MIA-2, Melanoma Inhibitor Activity Protein 2, human |
RC712-27 |
Bio Basic |
5ug |
EUR 125.26 |
|
Interleukin 27 (IL-27) Antibody |
20-abx225246 |
Abbexa |
-
EUR 444.00
-
EUR 727.20
-
EUR 376.80
|
|
|
Interleukin 27 (IL-27) Antibody |
abx234259-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
Interleukin 27 (IL-27) Antibody |
abx234260-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
27-Hydroxycholesterol (27-HC) ELISA Kit |
abx257403-96tests |
Abbexa |
96 tests |
EUR 764.4 |
|
Gap 27 |
A1045-10 |
ApexBio |
10 mg |
EUR 373.2 |
Description: Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker.Connexins, or gap junctions, are a family of structurally-related transmembrane proteins. |
Gap 27 |
A1045-25 |
ApexBio |
25 mg |
EUR 498 |
Description: Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker.Connexins, or gap junctions, are a family of structurally-related transmembrane proteins. |
Gap 27 |
A1045-5 |
ApexBio |
5 mg |
EUR 247.2 |
Description: Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker.Connexins, or gap junctions, are a family of structurally-related transmembrane proteins. |
27-Hydroxycholesterol |
B2988-1 |
Biovision |
1mg |
EUR 199.2 |
27-Hydroxycholesterol |
B2988-5 |
Biovision |
5mg |
EUR 612 |
GAP 27 |
H-7592.0500 |
Bachem |
0.5mg |
EUR 85.2 |
Description: Sum Formula: C60H101N15O17; CAS# [198284-64-9] net |
GAP 27 |
H-7592.1000 |
Bachem |
1.0mg |
EUR 122.4 |
Description: Sum Formula: C60H101N15O17; CAS# [198284-64-9] net |
27-Hydroxycholesterol |
TBZ2137 |
ChemNorm |
20mg |
Ask for price |
27-Deoxyactein |
TBZ2209 |
ChemNorm |
10mg |
Ask for price |
Human Peptide Histidine-Methionine 27 (PHM-27) peptide (27-aa, amide) |
PHM65-P-500 |
Alpha Diagnostics |
500 ug |
EUR 343.2 |
Rat Interleukin 27,IL-27 ELISA Kit |
CN-01431R1 |
ChemNorm |
96T |
EUR 520.8 |
Rat Interleukin 27,IL-27 ELISA Kit |
CN-01431R2 |
ChemNorm |
48T |
EUR 340.8 |
Human Interleukin 27, IL-27 ELISA Kit |
CSB-E08464h-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 27, IL-27 in samples from serum, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Interleukin 27, IL-27 ELISA Kit |
1-CSB-E08464h |
Cusabio |
-
EUR 723.60
-
EUR 5096.40
-
EUR 2712.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 27, IL-27 in samples from serum, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Rat Interleukin 27, IL-27 ELISA Kit |
CSB-E08465r-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 27, IL-27 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Rat Interleukin 27, IL-27 ELISA Kit |
1-CSB-E08465r |
Cusabio |
-
EUR 723.60
-
EUR 5096.40
-
EUR 2712.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 27, IL-27 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse Interleukin 27, IL-27 ELISA Kit |
CSB-E08466m-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 27, IL-27 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse Interleukin 27, IL-27 ELISA Kit |
1-CSB-E08466m |
Cusabio |
-
EUR 723.60
-
EUR 5096.40
-
EUR 2712.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 27, IL-27 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
human Interleukin 27,IL-27 ELISA Kit |
CN-03350H1 |
ChemNorm |
96T |
EUR 529.2 |
human Interleukin 27,IL-27 ELISA Kit |
CN-03350H2 |
ChemNorm |
48T |
EUR 349.2 |
Mouse Interleukin 27,IL-27 ELISA Kit |
CN-02300M1 |
ChemNorm |
96T |
EUR 537.6 |
Mouse Interleukin 27,IL-27 ELISA Kit |
CN-02300M2 |
ChemNorm |
48T |
EUR 356.4 |
Mouse IL-27(Interleukin 27) ELISA Kit |
EM1811 |
FN Test |
96T |
EUR 681.12 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 4.688pg/ml |
Canine Interleukin 27(IL-27)ELISA Kit |
GA-E0072CN-48T |
GenAsia Biotech |
48T |
EUR 482.4 |
Canine Interleukin 27(IL-27)ELISA Kit |
GA-E0072CN-96T |
GenAsia Biotech |
96T |
EUR 820.8 |
Human Interleukin 27(IL-27)ELISA Kit |
GA-E0115HM-48T |
GenAsia Biotech |
48T |
EUR 346.8 |
Human Interleukin 27(IL-27)ELISA Kit |
GA-E0115HM-96T |
GenAsia Biotech |
96T |
EUR 559.2 |
Rat Interleukin 27(IL-27)ELISA Kit |
GA-E0135RT-48T |
GenAsia Biotech |
48T |
EUR 403.2 |
Rat Interleukin 27(IL-27)ELISA Kit |
GA-E0135RT-96T |
GenAsia Biotech |
96T |
EUR 640.8 |
Human 27 OHC(27-Hydroxycholesterol) ELISA Kit |
EH4025 |
FN Test |
96T |
EUR 628.92 |
|
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375 ng/ml |
Rat IL-27(Interleukin 27) ELISA Kit |
ER1098 |
FN Test |
96T |
EUR 628.92 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml |
human Interleukin 27,IL-27 ELISA Kit |
201-12-0076 |
SunredBio |
96 tests |
EUR 528 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Mouse Interleukin 27 (IL-27) CLIA Kit |
abx197191-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Rat Interleukin 27 (IL-27) CLIA Kit |
abx197192-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Mouse Interleukin 27(IL-27)ELISA Kit |
GA-E0530MS-48T |
GenAsia Biotech |
48T |
EUR 403.2 |
Mouse Interleukin 27(IL-27)ELISA Kit |
GA-E0530MS-96T |
GenAsia Biotech |
96T |
EUR 640.8 |
IL-27 Interleukin-27 Mouse Recombinant Protein |
PROTQ8K3I6 |
BosterBio |
Regular: 10ug |
EUR 380.4 |
Description: Interleukin-27 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 207 amino acids and having a molecular mass of 23.7 kDa. ;The Murine IL-27 is purified by proprietary chromatographic techniques. |
IL-27 Interleukin-27 Human Recombinant Protein |
PROTQ8NEV9 |
BosterBio |
Regular: 5ug |
EUR 380.4 |
Description: IL-27 Human Recombinant produced in HEK cells is a glycosylated non-covalently heterodimer that consists of 2 chains, IL27A (IL27p28) having a Mw of 25kDa and IL27B (EBI3) having a Mw of 30kDa. Each chain migrates separately on SDS-PAGE. The IL-27 protein is purified by proprietary chromatographic techniques |
ELISA kit for Human IL-27 (Interleukin 27) |
E-EL-H2338 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 640.8 |
|
Description: A sandwich ELISA kit for quantitative measurement of Human IL-27 (Interleukin 27) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Mouse IL-27 (Interleukin 27) |
E-EL-M0732 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 640.8 |
|
Description: A sandwich ELISA kit for quantitative measurement of Mouse IL-27 (Interleukin 27) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Rat IL-27 (Interleukin 27) |
E-EL-R0570 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 640.8 |
|
Description: A sandwich ELISA kit for quantitative measurement of Rat IL-27 (Interleukin 27) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Rat IL-27 (Interleukin 27) |
E-EL-R1223 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 640.8 |
|
Description: A sandwich ELISA kit for quantitative measurement of Rat IL-27 (Interleukin 27) in samples from Serum, Plasma, Cell supernatant |
Recombinant Mouse Interleukin-27/IL-27 (C-6His) |
CS44-10ug |
Novoprotein |
10ug |
EUR 278.4 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Mouse Interleukin-27/IL-27 (C-6His) |
CS44-1mg |
Novoprotein |
1mg |
EUR 4322.4 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Mouse Interleukin-27/IL-27 (C-6His) |
CS44-500ug |
Novoprotein |
500ug |
EUR 3043.2 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Mouse Interleukin-27/IL-27 (C-6His) |
CS44-50ug |
Novoprotein |
50ug |
EUR 717.6 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
CLIA kit for Mouse IL-27 (Interleukin 27) |
E-CL-M0465 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 700.8 |
|
Description: A sandwich CLIA kit for quantitative measurement of Mouse IL-27 (Interleukin 27) in samples from Serum, Plasma, Cell supernatant |
CLIA kit for Rat IL-27 (Interleukin 27) |
E-CL-R0404 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 700.8 |
|
Description: A sandwich CLIA kit for quantitative measurement of Rat IL-27 (Interleukin 27) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Rabbit Interleukin 27 (IL-27) |
KTE90157-48T |
Abbkine |
48T |
EUR 457.2 |
|
Description: Quantitative sandwich ELISA for measuring Rabbit Interleukin 27 (IL-27) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rabbit Interleukin 27 (IL-27) |
KTE90157-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 3194.4 |
|
Description: Quantitative sandwich ELISA for measuring Rabbit Interleukin 27 (IL-27) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rabbit Interleukin 27 (IL-27) |
KTE90157-96T |
Abbkine |
96T |
EUR 802.8 |
|
Description: Quantitative sandwich ELISA for measuring Rabbit Interleukin 27 (IL-27) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
IL-27 Antibody |
3797-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
Description: IL-27 Antibody: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. |
IL-27 Antibody |
3797-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
Description: IL-27 Antibody: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. |
IL-27 Peptide |
3797P |
ProSci |
0.05 mg |
EUR 197.7 |
Description: (NT) IL-27 peptide |
IL-27 Antibody |
3799-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
Description: IL-27 Antibody: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. |
IL-27 Antibody |
3799-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
Description: IL-27 Antibody: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. |
IL-27 Peptide |
3799P |
ProSci |
0.05 mg |
EUR 197.7 |
Description: (IN) IL-27 peptide |
IL-27 Antibody |
24412-100ul |
SAB |
100ul |
EUR 468 |
IL-27 Antibody |
24413-100ul |
SAB |
100ul |
EUR 468 |
SeedG-27 Antibody |
abx018403-100ul |
Abbexa |
100 ul |
EUR 460.8 |
|
OsMYB-27 Antibody |
abx018575-100ul |
Abbexa |
100 ul |
EUR 460.8 |
|
PACAP 1-27 |
B5075-.5 |
ApexBio |
500 ?g |
EUR 277.2 |
PACAP 1-27 |
B5075-1 |
ApexBio |
1 mg |
EUR 348 |
PACAP 1-27 |
B5075-5 |
ApexBio |
5 mg |
EUR 927.6 |
PHM 27 (human) |
B5254-1 |
ApexBio |
1 mg |
EUR 478.8 |
FGIN-1-27 |
B6394-10 |
ApexBio |
10 mg |
EUR 151.2 |
FGIN-1-27 |
B6394-25 |
ApexBio |
25 mg |
EUR 205.2 |
FGIN-1-27 |
B6394-50 |
ApexBio |
50 mg |
EUR 327.6 |
PHI-27 (porcine) |
H-3730.0500 |
Bachem |
0.5mg |
EUR 400.8 |
Description: Sum Formula: C136H216N36O40; CAS# [80458-29-3] |
PHI-27 (porcine) |
H-3730.1000 |
Bachem |
1.0mg |
EUR 618 |
Description: Sum Formula: C136H216N36O40; CAS# [80458-29-3] |
PHM-27 (human) |
H-6355.0500 |
Bachem |
0.5mg |
EUR 400.8 |
Description: Sum Formula: C135H214N34O40S; CAS# [87403-73-4] net |
PHM-27 (human) |
H-6355.1000 |
Bachem |
1.0mg |
EUR 618 |
Description: Sum Formula: C135H214N34O40S; CAS# [87403-73-4] net |
PHI-27 (rat) |
H-7760.0500 |
Bachem |
0.5mg |
EUR 400.8 |
Description: Sum Formula: C136H216N36O41; CAS# [96849-38-6] |
PHI-27 (rat) |
H-7760.1000 |
Bachem |
1.0mg |
EUR 618 |
Description: Sum Formula: C136H216N36O41; CAS# [96849-38-6] |
27-Hydroxymangiferonic acid |
TB02479 |
ChemNorm |
5mg |
EUR 1164 |
121817-27-4 |
TBZ30118 |
ChemNorm |
unit |
Ask for price |
Rat heat shock protein 27,HSP-27 ELISA Kit |
CN-01689R1 |
ChemNorm |
96T |
EUR 526.8 |
Rat heat shock protein 27,HSP-27 ELISA Kit |
CN-01689R2 |
ChemNorm |
48T |
EUR 348 |
Rat heat shock protein 27, HSP-27 ELISA Kit |
CSB-E09240r-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Rat heat shock protein 27, HSP-27 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Rat heat shock protein 27, HSP-27 ELISA Kit |
1-CSB-E09240r |
Cusabio |
-
EUR 843.60
-
EUR 5811.60
-
EUR 3084.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Rat heat shock protein 27, HSP-27 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Chicken Heat Shock Protein 27, HSP-27 ELISA Kit |
CSB-E12879C-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativecompetitive ELISA kit for measuring Chicken Heat Shock Protein 27, HSP-27 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Chicken Heat Shock Protein 27, HSP-27 ELISA Kit |
1-CSB-E12879C |
Cusabio |
-
EUR 843.60
-
EUR 5811.60
-
EUR 3084.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativecompetitive ELISA kit for measuring Chicken Heat Shock Protein 27, HSP-27 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human heat shock protein 27,HSP-27 ELISA Kit |
CN-04317H1 |
ChemNorm |
96T |
EUR 526.8 |
Human heat shock protein 27,HSP-27 ELISA Kit |
CN-04317H2 |
ChemNorm |
48T |
EUR 348 |
Mouse heat shock protein 27,HSP-27 ELISA Kit |
CN-02561M1 |
ChemNorm |
96T |
EUR 556.8 |
Mouse heat shock protein 27,HSP-27 ELISA Kit |
CN-02561M2 |
ChemNorm |
48T |
EUR 375.6 |
Mouse HSP-27(heat shock protein 27) ELISA Kit |
EM1135 |
FN Test |
96T |
EUR 571.5 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.375 ng/ml |
Rat HSP-27(Heat Shock Protein 27) ELISA Kit |
ER1053 |
FN Test |
96T |
EUR 571.5 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.469 ng/ml |
Rat Heat Shock Protein 27 (HSP-27) CLIA Kit |
abx197103-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Human heat shock protein 27,HSP-27 ELISA Kit |
201-12-1787 |
SunredBio |
96 tests |
EUR 528 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Human IL-27(Interleukin-27 subunit alpha) ELISA Kit |
EH0193 |
FN Test |
96T |
EUR 628.92 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml |
IL-27 ELISA Kit| Rat Interleukin 27 ELISA Kit |
EF017845 |
Lifescience Market |
96 Tests |
EUR 826.8 |
Apparently, therapy with AM630, a CB2R antagonist was noticed to abrogate the protecting results of BCP on the biochemical and molecular parameters besides hyperlipidemia and ionic homeostasis in ISO-induced MI in rats. The current examine findings display that BCP possess the potential to guard myocardium towards ISO-induced MI in a CB2-dependent and impartial method.
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