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    • Development of hMC1R Selective Small Agonists for Sunless Tanning and Prevention of Genotoxicity of UV in Melanocytes

    Activation of the human melanocortin 1 receptor (hMC1R) expressed on melanocytes by α-melanocortin (α-MSH) performs a central function in regulating human pigmentation, and lowering the genotoxicity of ultraviolet radiation (UV) by activating DNA restore and antioxidant defenses. In the direction of growth of a hMC1R-targeted photoprotection technique we designed tetra- and tripeptide agonists with modifications

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    • Anti-PTSD Effects of Hypidone Hydrochloride (YL-0919): A Novel Combined Selective 5-HT Reuptake Inhibitor/5-HT 1A Receptor Partial Agonist/5-HT 6 Receptor Full Agonist

    Posttraumatic stress dysfunction (PTSD) is a debilitating trauma and stressor-related dysfunction that has develop into a serious neuropsychiatric downside, resulting in substantial disruptions in particular person well being and societal prices. Our earlier research have demonstrated that hypidone hydrochloride (YL-0919), a novel mixed selective 5-HT reuptake inhibitor/5-HT1A receptor partial agonist/5-HT6 receptor full agonist, exerts notable antidepressant- and

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    • Design and Immunological Evaluation of a Hybrid Peptide as a Potent TLR2 Agonist by Structure-Based Virtual Screening

    Immunity is a flexible defensive response that’s concerned in defending in opposition to illness by figuring out and destroying self and non-self dangerous substances. As a state of non permanent or everlasting immune dysfunction, immunosuppression could make an organism extra inclined to an infection, organ harm, and most cancers attributable to harm to the immune

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